• 術後感染予防抗菌薬適正使用のための実践ガイドライン (日本化学療法学会/日本外科感染症学会、追補版 2021) 委員長
• 侵襲性カンジダ症に対するマネジメントのための臨床実践ガイドライン（日本医真菌学会 2021）委員長
• 抗菌薬TDM臨床実践ガイドライン（日本化学療法学会/日本TDM学会　2022）委員長
• MRSA感染症の治療ガイドライン（日本化学慮法学会/日本感染症学会 改訂版2019） 副委員長

• 第68回日本化学療法学会学術総会：2020年9月12日～14日 (神戸国際会議場, 神戸ポートピアホテル)、 テーマ：COVID-19との戦いで学んだこと第3波に向けて準備すべきこと：目指せ、わが国で実践する Antimicrobial stewardship

• MRSAフォーラム代表世話人：2020年～（在任中）
• 日本嫌気性菌学会：理事 2014年～2期任期満了、監事 2019年～（在任中）
• 日本環境感染学会理事： 2006年～ 2期任期満了、2012年～ 2期任期満了
• 日本化学療法学会理事：2006年～ 2期任期満了、2012年～ 2期任期満了、2018年～ 2期任期満了
• 日本感染症学会；理事　2015年～ 2期任期満了
• 日本外科感染症学会：理事2005年～2020年（任期満了）
• 日本医真菌学会：監事 2019年～2期任期満了
• International Society of Antimicrobial Chemotherapy：Executive committee 2019～2020年

新興・再興感染症に対する革新的医薬品等開発推進研究事業　研究開発課題：「侵襲性酵母感染症の病原性解明と疫学・診断法・制御法の研究」 「侵襲性酵母感染症の診断・治療法の研究開発と薬剤耐性カンジダ症の疫学研究」

• 2017年4月～2020年3月分担課題：カンジダ血症診療ガイドラインの検証と新しいエビデンスの確立
• 2020年4月～2023年3月　　同上
• 2023年4月～2026年3月　　同上　

• AST虎の巻「日常の疑問に答える」2020　中外医学社 編者

• 志賀潔・秦佐八郎記念賞　2021年
• 日本嫌気性菌感染症学会賞　2022年

（MRSA 15編、外科感染 13編、真菌 10編、抗菌薬適正使用 7編、サーベイランス 7編、ワクチン6編、新型コロナウイルス 4編、眼科4編、新規抗菌薬2編）
★…重要論文

1) ★Makino M, Takesue Y, Murakami Y, Morosawa M, Doi M, Ogashiwa H, Ueda T, Nakajima K, Sugiura H, Nozaki Y: Influence of easing COVID-19 strategies following downgrading of the national infectious disease category on COVID-19 occurrence among hospitalized patients in Japan. J Infect Chemother. 2025; 31:102464. doi: 10.1016/j.jiac.2024.07.004.

2) Kondo H, Ikawa F, Mayumi T, Takesue Y, Uchimura M, Mikuni N, Horie N: Questionnaire-based Survey on the Prevention of Surgical Site Infection after the Publication of Its Guidelines for Neurosurgery in Japan. Neurol Med Chir (Tokyo). 2025; 65:141-147. 

3) Murakami Y, Shibata S, Morosawa M, Nozaki Y, Takesue Y: Delayed Pulmonary Manifestations of Miliary Tuberculosis Following a Normal Initial High-Resolution Computed Tomography. Cureus. 2025; 17: e77098. doi: 10.7759/cureus.77098. eCollection

4) Asaeda T, Ueda T, Nozaki Y, Murakami Y, Morosawa M, Inaba H, Ogashiwa H, Doi M, Nakajima K, Shirakawa M, Nakamura A, Ikeda N, Sugiyama Y, Wada Y, Ito T, Takesue Y: Clinical features of pasteurellosis without an animal bite or scratch in comparison with bite/scratch pasteurellosis. J Infect Chemother. 2024; 30:820-823. doi: 10.1016/j.jiac.2024.02.002

5) Yoshimura A, Ishikawa H, Uchida K, Takesue Y, Mori J, Kinoshita T, Morikawa S, Okamoto F, Sawada T, Ohji M, Kanda T, Takeuchi M, Miki A, Kusuhara S, Ueda T, Ogata N, Sugimoto M, Kondo M, Yoshida S, Ogata T, Kimura K, Mitamura Y, Jujo T, Takagi H, Terasaki H, Sakamoto T, Sugisawa T, Komuku-Yamamoto Y: Risk Factors for Legal Blindness in 237 Japanese Patients with Exogenous Endophthalmitis: A Multicenter Cohort Study from J-CREST. Gomi F. Ocul Immunol Inflamm. 2024; 32:1133-1141.

6) ★Doi M, Takesue Y, Makino M, Kihara Y, Tanikawa A, Murakami Y, Ogashiwa H, Nakano Y, Nakama S, Ueda T, Nakajima K, Nozaki Y: Effect of a blood culture collection bundle on decreasing the contamination rate. PLoS One;19: e0314649. doi: 10.1371/journal.pone.0314649.

7) Murakami Y, Morosawa M, Nozaki Y, Takesue Y: Legionella Pneumonia Undetected by Repeated Urinary Antigen Testing With Ribotest® Legionella. Cureus. 2024; 16: e74035.

8) ★Ueda T, Nakajima K, Ichiki K, Ishikawa K, Yamada K, Tsuchida T, Otani N, Takubo S, Iijima K, Uchino M, Horio Y, Kuwahara R, Kimura T, Murakami Y, Nozaki Y, Nakama S, Miyazaki Y, Takesue Y: Association between the hypokalaemia index based on area over the serum potassium concentration curve and occurrence of acute kidney injury in patients administered liposomal amphotericin B. Mycoses. 2024;67:e13771. doi: 10.1111/myc.13771

9) Otani N, Nakajima K, Yamada K, Ishikawa K, Ichiki K, Ueda T, Takesue Y, Yamamoto T, Higasa S, Tanimura S, Inai Y, Okuno T: Timing of Assessment of Humoral and Cell-Mediated Immunity after Influenza Vaccination. Vaccines (Basel). 2024 May 27;12(6):584. doi: 10.3390/vaccines12060584

10) ★Murakami Y, Nozaki Y, Morosawa M, Toyama M, Ogashiwa H, Ueda T, Nakajima K, Tanaka R, Takesue Y: Difference in the impact of coinfections and secondary infections on antibiotic use in patients hospitalized with COVID-19 between the Omicron-dominant period and the pre-Omicron period. Infect Chemother. 2024; 30:853-859. doi: 10.1016/j.jiac.2024.02.026.

11) Oda K, Matsumoto K, Shoji K, Shigemi A, Kawamura H, Takahashi Y, Katanoda T, Hashiguchi Y, Jono H, Saito H, Takesue Y, Kimura T: Validation and development of population pharmacokinetic model of vancomycin using a real-world database from a nationwide free web application. J Infect Chemother. 2024; 30:1244-1251. doi: 10.1016/j.jiac.2024.05.014. 

12) Hanai Y, Oda K, Ueda T, Matsumoto K, Murakami L, Uekusa S, Ohashi H, Nishimura K, Takesue Y, Matsuo K: Optimal teicoplanin trough concentration with Therapeutic Drug Monitoring in children: A Systematic Review and Meta-analysis. Ther Drug Monit. 2024 Jul 9. doi: 10.1097/FTD.0000000000001230.

13) ★Hanai Y, Ueda T, Hamada Y, Oda K, Takahashi Y, Nakajima K, Miyazaki Y, Kiriyama M, Uekusa S, Matsuo K, Matsumoto K, Kimura T, Takesue Y: Optimal timing for therapeutic drug monitoring of voriconazole to prevent adverse effects in Japanese patients. Mycoses. 2023 Dec;66(12):1035-1044. doi: 10.1111/myc.13639.

14) Yoshimura A, Ishikawa H, Uchida K, Takesue Y, Mori J, Kinoshita T, Morikawa S, Okamoto F, Sawada T, Ohji M, Kanda T, Takeuchi M, Miki A, Kusuhara S, Ueda T, Ogata N, Sugimoto M, Kondo M, Yoshida S, Ogata T, Kimura K, Mitamura Y, Jujo T, Takagi H, Terasaki H, Sakamoto T, Sugisawa T, Komuku-Yamamoto Y, Gomi F: Risk Factors for Legal Blindness in 237 Japanese Patients with Exogenous Endophthalmitis: A Multicenter Cohort Study from J-CREST. Ocul Immunol Inflamm. 2024; 32:1133-1141.

15) Otani N, Shima M, Ueda T, Nakajima K, Takesue Y, Yamamoto T, Okuno T: Changes in the Epidemiology of Rubella: The Influence of Vaccine-Introducing Methods and COVID-19. Vaccines (Basel). 2023 Aug 12;11(8):1358. doi: 10.3390/vaccines11081358.

16) Samura M, Takada K, Hirose N, Kurata T, Nagumo F, Uchida M, Inoue J, Tanikawa K, Enoki Y, Taguchi K, Matsumoto K, Ueda T, Fujimura S, Mikamo H, Takesue Y, Mitsutake K: Comparison of the efficacy and safety of standard- and high-dose daptomycin: A systematic review and meta-analysis. Br J Clin Pharmacol. 2023 Apr;89(4):1291-1303. doi: 10.1111/bcp.15671.

17) Sugisawa T, Ishikawa H, Uchida K, Takesue Y, Mori J, Kinoshita T, Morikawa S, Okamoto F, Sawada T, Ohji M, Kanda T, Takeuchi M, Miki A, Kusuhara S, Ueda T, Ogata N, Sugimoto M, Kondo M, Yoshida S, Ogata T, Kimura K, Mitamura Y, Jujo T, Takagi H, Terasaki H, Sakamoto T, Komuku Y, Gomi F: Risk Factors for Legal Blindness in 77 Japanese Patients with Endogenous Endophthalmitis: A Multicenter Cohort Study from J-CREST. Ocul Immunol Inflamm. 2023 Sep;31(7):1505-1512. doi: 10.1080/09273948.2022.2112237.

18) ★Ueda T, Takesue Y, Nakajima K, Ichiki K, Ishikawa K, Yamada K, Tsuchida T, Otani N, Takahashi Y, Ishihara M, Takubo S, Iijima K, Ikeuchi H, Uchino M, Kimura T: Correlation between Antimicrobial Resistance and the Hospital-Wide Diverse Use of Broad-Spectrum Antibiotics by the Antimicrobial Stewardship Program in Japan. Pharmaceutics. 2023 Feb 3;15(2):518. doi: 10.3390/pharmaceutics15020518

19) ★Hanai Y, Ueda T, Hamada Y, Oda K, Takahashi Y, Nakajima K, Miyazaki Y, Kiriyama M, Uekusa S, Matsuo K, Matsumoto K, Kimura T, Takesue Y: Optimal timing for therapeutic drug monitoring of voriconazole to prevent adverse effects in Japanese patients. Mycoses. 2023 Aug 16. doi: 10.1111/myc.13639

20) ★Morosawa M, Ueda T, Nakajima K, Inoue T, Toyama M, Ogasiwa H, Doi M, Nozaki Y, Murakami Y, Ishii M, Takesue Y: Comparison of antibiotic use and antibiotic resistance between a community hospital and tertiary care hospital for evaluation of the antimicrobial stewardship program in Japan. PLoS One. 2023 Apr 24;18(4):e0284806. doi: 10.1371/journal.pone.0284806. eCollection 2023

21) ★Murakami Y, Ogashiwa H, Nozaki Y, Ueda T, Nakajima K, Morosawa M, Doi M, Makino M, Takesue Y: Judicious ending of isolation based on reverse transcription-polymerase chain reaction (RT-PCR) cycle threshold only for patients with coronavirus disease 2019 (COVID-19) requiring in-hospital therapy for longer than 20 days after symptom onset. J Infect Chemother. 2023 Aug;29(8):778-782. doi: 10.1016/j.jiac.2023.05.007. 

22) ★Hanai Y, Takahashi Y, Niwa T, Mayumi T, Hamada Y, Kimura T, Matsumoto K, Fujii S, Takesue Y: Clinical practice guidelines for therapeutic drug monitoring of teicoplanin: a consensus review by the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring. J Antimicrob Chemother. 2022 Mar 31;77(4):869-879. doi: 10.1093/jac/dkab499

23) ★Kazuaki Matsumoto, Kazutaka Oda, Kensuke Shoji, Yuki Hanai, Yoshiko Takahashi, Satoshi Fujii, Yukihiro Hamada, Toshimi Kimura, Toshihiko Mayumi, Takashi Ueda, Kazuhiko Nakajima, Yoshio Takesue: Clinical Practice Guidelines for Therapeutic Drug Monitoring of Vancomycin in the Framework of Model-Informed Precision Dosing: A Consensus Review by the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring. Pharmaceutics 2022, 14, 489; https://doi.org/10.3390/pharmaceutics14030489

24) ★Takesue Y, Hanai Y, Oda K, Hamada Y, Ueda T, Mayumi T, Matsumoto K, Fujii S, Takahashi Y, Miyazaki Y, Kimura T; Japanese Antimicrobial Therapeutic Drug Monitoring Guideline Committee: Clinical Practice Guideline for the Therapeutic Drug Monitoring of Voriconazole in Non-Asian and Asian Adult Patients: Consensus Review by the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring. Clin Ther. 2022 Dec;44(12):1604-1623. doi: 10.1016/j.clinthera.2022.10.005

25) Samura M, Kitahiro Y, Tashiro S, Moriyama H, Hamamura Y, Takahata I, Kawabe R, Enoki Y, Taguchi K, Takesue Y, Matsumoto K: Efficacy and Safety of Daptomycin versus Vancomycin for Bacteremia Caused by Methicillin-Resistant Staphylococcus aureus with Vancomycin Minimum Inhibitory Concentration > 1 µg/mL: A Systematic Review and Meta-Analysis. Pharmaceutics. 2022 Mar 27;14(4):714. doi: 10.3390/pharmaceutics14040714

26) ★Ogura H, Gohda J, Lu X, Yamamoto M, Takesue Y, Son A, Doi S, Matsushita K, Isobe F, Fukuda Y, Huang TP, Ueno T, Mambo N, Murakami H, Kawaguchi Y, Inoue JI, Shirai K, Yamasaki S, Hirata JI, Ishido S: Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19. Nat Commun. 2022 Dec 16;13(1):7063. doi: 10.1038/s41467-022-34655-1

27) Shoji K, Saito J, Nakamura H, Matsumoto K, Oda K, Takesue Y, Miyairi I: Current Aspects of Pediatric Pharmacokinetics and Pharmacodynamics of Antimicrobials in Japan: Importance of the Promotion of Population PK/PD Analysis. Pediatr Infect Dis J. 2022 Oct 1;41(10):e418-e423. doi: 10.1097/INF.0000000000003622

28) Otani N, Nakajima K, Ishikawa K, Ichiki K, Yoda Y, Ueda T, Takesue Y, Yamamoto T, Tanimura S, Shima M, Okuno T: Comparison of the Hemagglutination Inhibition Titers against Influenza Vaccine Strains in Japan from the 2017/2018 to 2021/2022 Seasons Using a Single Set of Serum Samples. Viruses. 2022 Jun 30;14(7):1455. doi: 10.3390/v14071455

29) ★Hasegawa T, Tashiro S, Mihara T, Kon J, Sakurai K, Tanaka Y, Morita T, Enoki Y, Taguchi K, Matsumoto K, Nakajima K, Takesue Y: Efficacy of surgical skin preparation with chlorhexidine in alcohol according to the concentration required to prevent surgical site infection: meta-analysis. BJS Open. 2022 Sep 2;6(5):zrac111. doi: 10.1093/bjsopen/zrac111

30) ★Ueda T, Takesue Y, Nakajima K, Ichiki K, Ishikawa K, Yamada K, Tsuchida T, Otani N, Takahashi Y, Ishihara M, Takubo S, Ikeuchi H, Uchino M, Kimura T, Matsumoto K, Oda K, Kimura T. Validation of Vancomycin Area under the Concentration-Time Curve Estimation by the Bayesian Approach Using One-Point Samples for Predicting Clinical Outcomes in Patients with Methicillin-Resistant Staphylococcus aureus Infections. Antibiotics (Basel). 2022 Jan 13;11(1):96. doi: 10.3390/antibiotics11010096

31) Kuwahara R, Uchino M, Ikeuchi H, Bando T, Sasaki H, Yasuhara M, Kimura K, Goto Y, Horio Y, Minagawa T, Ikeda M, Ueda T, Takesue Y. Effect of Changing Surgical Instruments Before Wound Closure to Prevent Wound Infection in Lower GI Surgery: A Randomized Controlled Trial. Dis Colon Rectum. 2022 Jan 1;65(1):100-107. doi: 10.1097/DCR.0000000000002035.

32) Ueda T, Takesue Y, Nakajima K, Ichiki K, Ishikawa K, Yamada K, Tsuchida T, Otani N, Ide T, Takeda K, Nishi S, Takahashi Y, Ishihara M, Takubo S, Ikeuchi H, Uchino M, Kimura T. Enhanced loading dose of teicoplanin for three days is required to achieve a target trough concentration of 20 μg/mL in patients receiving continuous venovenous haemodiafiltration with a low flow rate. J Infect Chemother. 2022 Feb;28(2):232-237. doi: 10.1016/j.jiac.2021.10.023

33) Shinkawa H, Kubo S, Mikamo H, Matsuda N, Omura K, Okamoto K, Ono S, Obara H, Kobayashi M, Sasaki J, Shimizu J, Sueyoshi S, Yoshida J, Watanabe M, Takesue Y. Survey on the current status of the indication and implementation protocols for bile replacement in patients with external biliary drainage with special reference to infection control. Surg Today. 2022 Oct;52(10):1446-1452. doi: 10.1007/s00595-022-02475-x.

34) Ikeuchi H, Uchino M, Bando T, Horio Y, Kuwahara R, Minagawa T, Goto Y, Kusunoki K, Ikeda M, Beppu N, Takesue Y: Localization of recurrent lesions following ileocolic resection for Crohn's disease. BMC Surg. 2021 Mar 20;21(1):145. doi: 10.1186/s12893-020-00980-9

35) Ishikawa H, Uchida K, Takesue Y, Mori J, Kinoshita T, Morikawa S, Okamoto F, Sawada T, Ohji M, Kanda T, Takeuchi M, Miki A, Kusuhara S, Ueda T, Ogata N, Sugimoto M, Kondo M, Yoshida S, Ogata T, Kimura K, Mitamura Y, Jujo T, Takagi H, Terasaki H, Sakamoto T, Sugisawa T, Komuku Y, Gomi F: Clinical Characteristics and Outcomes in 314 Japanese Patients with Bacterial Endophthalmitis: A Multicenter Cohort Study from J-CREST. Pathogens. 2021 Mar 24;10(4):390. doi: 10.3390/pathogens10040390

36) Nakada-Motokawa N, Miyazaki T, Ueda T, Yamagishi Y, Yamada K, Kawamura H, Kakeya H, Mukae H, Mikamo H, Takesue Y, Kohno S. Modified Pitt bacteremia score for predicting mortality in patients with candidaemia: A multicentre seven-year retrospective study conducted in Japan. Mycoses. 2021 Dec;64(12):1498-1507. doi: 10.1111/myc.13380.

37) Yanagihara K, Kosai K, Mikamo H, Mukae H, Takesue Y, Abe M, Taniguchi K, Petigara T, Kaku M. Serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae associated with invasive pneumococcal disease among adults in Japan. Int J Infect Dis. 2021 Jan;102:260-268. doi: 10.1016/j.ijid.2020.10.017

38) ★Hashimoto N, Kimura T, Hamada Y, Niwa T, Hanai Y, Chuma M, Fujii S, Matsumoto K, Shigemi A, Kawamura H, Takahashi Y, Takesue Y: Candidates for area under the concentration-time curve (AUC)-guided dosing and risk reduction based on analyses of risk factors associated with nephrotoxicity in vancomycin-treated patients. J Glob Antimicrob Resist. 2021 Dec;27:12-19. doi: 10.1016/j.jgar.2021.07.018.

39) ★Ueda T, Takesue Y, Matsumoto T, Tateda K, Kusachi S, Mikamo H, Sato J, Hanaki H, Mizuguchi T, Morikane K, Kobayashi M, Harihara Y, Seki S, Ishida Y, Fukushima R, Hada M, Matsuo Y, Kubo S, Kimura Y, Hata H, Nakajima K, Ohge H, Akagi S, Takeda S, Fukui Y, Suzuki K, Okamoto K, Yanagihara K, Kawamura H: Change in antimicrobial susceptibility of pathogens isolated from surgical site infections over the past decade in Japanese nation-wide surveillance study. J Infect Chemother. 2021 Jul;27(7):931-939. doi:10.1016/j.jiac.2021.03.010. 

40) Otani, N.; Nakajima, K.; Ishikawa, K.; Ichiki, K.; Ueda, T.; Takesue, Y; Yamamoto, T.; Tanimura, S.; Shima, M.; Okuno, T. Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination. Viruses 2021, 13, 1137.

41) ★Oda K, Hashiguchi Y, Kimura T, Tsuji Y, Shoji K, Takahashi Y, Matsumoto K, Kawamura H, Saito H, Takesue Y: Performance of Area under the Concentration-Time Curve Estimations of Vancomycin with Limited Sampling by a Newly Developed Web Application. Pharm Res. 2021;38:637-646.

42) Hanai Y, Hamada Y, Kimura T, Matsumoto K, Takahashi Y, Fujii S, Nishizawa K, Miyazaki Y, Takesue Y: Favorable Effects of Voriconazole Trough Concentrations Exceeding 1 mug/mL on Treatment Success and All-Cause Mortality: A Systematic Review and Meta-Analysis. J Fungi (Basel). 2021;7:306. 

43) ★Moeko Tsutsuura; Hiromu Moriyama; Nana Kojima; Yuki Mizukami; Sho Tashiro; Sumika Osa; Yuki Enoki; Kazuaki Taguchi; Kazutaka Oda; Satoshi Fujii; Yoshiko Takahashi; Yukihiro Hamada; Toshimi Kimura; Yoshio Takesue; Kazuaki Matsumoto：The monitoring of vancomycin: a systematic review and meta-analyses of area under the concentration-time curve-guided dosing and trough-guided dosing. BMC Infectious Diseases. 2021 Feb 6;21(1):153. 

44) ★Hamada Y, Ueda T, Miyazaki Y, Nakajima K, Fukunaga K, Miyazaki T, Nakada-Motokawa N, Nagao M, Kawamura H, Shigemi A, Ebihara F, Kimura T, Ikegame K, Uchino M, Ikeuchi H, Takesue Y: Effects of antifungal stewardship using therapeutic drug monitoring in voriconazole therapy on the prevention and control of hepatotoxicity and visual symptoms: A multicentre study conducted in Japan. Mycoses.2021 ;63(8):779-786.

45) Yuki Hanai, Yoshiko Takahashi, Takashi Niwa, Toshihiko Mayumi, Yukihiro Hamada, Toshimi Kimura, Kazuaki Matsumoto, Satoshi Fujii, Yoshio Takesue: Optimal trough concentration of teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus infection: A systematic review and meta-analysis. J Clin Pharm Ther. 2021 Feb 6. Online ahead of print.

46) Yuki Hanai, Yukihiro Hamada, Toshimi Kimura, Kazuaki Matsumoto, Yoshiko Takahashi,　Satoshi Fujii, Kenji Nishizawa, Yoshio Takesue: Optimal trough concentration of voriconazole with therapeutic drug monitoring in children: A systematic review and meta-analysis. J Infect Chemother. 2021; 27:151-160

47) Hiromu Moriyama, Moeko Tsutsuura, Nana Kojima, Yuki Mizukami, Sho Tashiro, Sumika Osa, Yuki Enoki, Kazuaki Taguchi, Kazutaka Oda, Satoshi Fujii, Yoshiko Takahashi, Yukihiro Hamada, Toshimi Kimura, Yoshio Takesue, Kazuaki Matsumoto: The optimal trough-guided monitoring of vancomycin in children: systematic review and meta-analyses. J Infect Chemother. 2021 Feb 6:S1341-321X(21)00027-1. Online ahead of print

48) Tomoyuki Yamada, Satoshi Fujii, Akari Shigemi, Yoshio Takesue: A meta-analysis of the target trough concentration of gentamicin and amikacin for reducing the risk of nephrotoxicity. J Infect Chemother. 2021; 27:256-261.

49) Oda K, Fujii S, Yamamoto T, Mayumi T, Takesue Y: Evaluation of once-daily dosing and target concentrations in therapeutic drug monitoring for arbekacin: A meta-analysis. J Infect Chemother. 2021; 27:26-31.

50) Ueda T, Takesue Y, Nakajima K, Ichiki K, Ishikawa K, Takai Y, Yamada K, Wada Y, Tsuchida T, Otani N, Takahashi Y, Ishihara M, Shibata S, Ikeuchi H, Uchino M, Kimura T. Vancomycin loading dose is associated with increased early clinical response without attainment of initial target trough concentration at a steady state in patients with methicillin-resistant Staphylococcus aureus infections. J Clin Pharm Ther 2020 Aug;45(4):682-690

51) Osa S, Tashiro S, Igarashi Y, Watabe Y, Liu X, Enoki Y, Taguchi K, Mayumi T, Miyazaki Y, Takesue Y, Matsumoto K.: Azoles versus conventional amphotericin B for the treatment of candidemia: a meta-analysis of randomized controlled trials. J Infect Chemother. 2020 Nov;26(11):1232-1236

52) Mori M, N Ikeda, A Taketomi, Y Asahi, Y Takesue, T Orimo, M Ono, T Kuwayama, Se Nakamura, Y Yamada, T Kuroda, K Yuzawa, T Hibi, H Nagano, M Unno, Y Kitagawa: COVID-19: Clinical issues from the Japan Surgical Society. Surg Today 2020 Aug;50(8):794-808

53) Otani N, Shima M, Tanimura S, Ueda T, Ichiki K, Nakajima K, Takesue Y, Honjo K, Okuno T. Sensitivity and specificity of different antibody tests for detecting varicella-zoster virus. J Infect Chemother. 2020 Aug 22:S1341-321

54) Mimura Y, Yahiro M, Masumoto M, Fukui R, Okamoto R, Aichi M, Mihara Y, Ueda T, Takesue Y, Ikawa K, Morikawa N, Kuragano T. The pharmacokinetics of oral metronidazole in patients with metronidazole‐induced encephalopathy undergoing maintenance hemodialysis. Hemodialysis International. First published: 30 July 2020.

55) Mochizuki Y, Ishikawa H, Sato A, Yamada K, Takesue Y, Gomi F. Pasteurella multocida-induced endophthalmitis after a cat scratch. Am J Ophthalmol Case Rep. 2020 Apr 16;18:100711..

56) ★Ueda T, Takesue Y, Nakajima K, Ichiki K, Ishikawa K, Takai Y, Yamada K, Tsuchida T, Otani N, Takahashi Y, Ishihara M, Shibata S, Ikeuchi H, Uchino M, Kimura T. Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days. BMC Pharmacol Toxicol. 2020 Jul 8;21(1):50

57) Tashiro S, Osa S, Igarashi Y, Watabe Y, Liu X, Enoki Y, Taguchi K, Mayumi T, Miyazaki Y, Takesue Y, Matsumoto K.: Echinocandins versus non-echinocandins for the treatment of invasive candidiasis: A meta-analysis of randomized controlled trials. J Infect Chemother. 2020 Nov;26(11):1164-1176

58) ★Yoneda A, Takesue Y, Takahashi Y, Ichiki K, Tsuchida T, Ikeuchi H, Uchino M, Hatano E, Shinohara H, Tomita N. Improvement in Hyperglycemia Prevents Surgical Site Infection Irrespective of Insulin Therapy in Non-diabetic Patients Undergoing Gastrointestinal Surgery. World J Surg. 2020; 44(5):1450-1458. doi: 10.1007/s00268-020-05371-y.

59) Yamashita C, Takesue Y, Matsumoto K, Ikegame K, Enoki Y, Uchino M, Miyazaki T, Izumikawa K, Takada T, Okinaka K, Ueda T, Miyazaki Y, Mayumi T. Echinocandins versus non-echinocandins for empirical antifungal therapy in patients with hematological disease with febrile neutropenia: A systematic review and meta-analysis. J Infect Chemother. 2020; 1341-1321 (20) 30029-5.

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